[Digoxin-related leukocytoclastic vasculitis in a very elderly woman: A case report].
Identifieur interne : 000900 ( Main/Exploration ); précédent : 000899; suivant : 000901[Digoxin-related leukocytoclastic vasculitis in a very elderly woman: A case report].
Auteurs : S. Ludwig-Béal [France] ; N. Vernier [France] ; L. Popitean [France] ; L. Levêque [France] ; S. Combret [France] ; P. Manckoundia [France]Source :
- Journal des maladies vasculaires [ 2214-8116 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Vascularite leucocytoclasique cutanée.
- effets indésirables : Digoxine.
- traitement médicamenteux : Fibrillation auriculaire.
- Biopsie, Femelle, Humains, Sujet âgé de 80 ans ou plus, Vascularite leucocytoclasique cutanée.
- mix :
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Digoxin.
- chemically induced : Vasculitis, Leukocytoclastic, Cutaneous.
- drug therapy : Atrial Fibrillation.
- pathology : Vasculitis, Leukocytoclastic, Cutaneous.
- Aged, 80 and over, Biopsy, Female, Humans.
- mix :
Abstract
Even though digoxin causes many side effects, few cases of skin involvement are recorded in the French Pharmacovigilance Database. We report a case of leukocytoclastic vasculitis (LV) very probably due to digoxin. A 91-year-old woman, hospitalized following a fall, presented cardiac decompensation in a context of rapid atrial fibrillation requiring treatment with digoxin. Eight days later, a rash appeared on her back and trunk. It was neither itchy, nor painful and persisted despite local treatment. There were no other clinical anomalies. After a few days, the rash spread with appearance of bullous lesions, ulcerations and a necrosis on lymphedema of the two legs. Among the complementary examinations, skin biopsy revealed LV with necrosis and subepidermal detachment suggested toxic dermal necrolysis, while direct immunofluorescence was negative. The rash resolved progressively once the digoxin was stopped. The pharmacovigilance department recorded that digoxin was the probable cause. The evidence allowed us to conclude that digoxin was the cause.
Url:
DOI: 10.1016/j.jmv.2016.02.002
PubMed: 26970812
Affiliations:
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Le document en format XML
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Ludwig-Béal</name><affiliation wicri:level="3"><nlm:affiliation>Centre de convalescence gériatrique de Fontaine, 67, route d'Ahuy, 21210 Fontaine-les-Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de convalescence gériatrique de Fontaine, 67, route d'Ahuy, 21210 Fontaine-les-Dijon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Fontaine-les-Dijon</settlement></placeName></affiliation></author><author><name sortKey="Vernier, N" sort="Vernier, N" uniqKey="Vernier N" first="N" last="Vernier">N. Vernier</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne et maladies systémiques, CHU Dijon bocage central, 2, boulevard de Lattre-de-Tassigny, 21000 Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne et maladies systémiques, CHU Dijon bocage central, 2, boulevard de Lattre-de-Tassigny, 21000 Dijon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Popitean, L" sort="Popitean, L" uniqKey="Popitean L" first="L" last="Popitean">L. 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Levêque</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot CHU, BP 87909, 2, rue Jules-Violle, 21079 Dijon cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne gériatrie, hôpital de Champmaillot CHU, BP 87909, 2, rue Jules-Violle, 21079 Dijon cedex</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Combret, S" sort="Combret, S" uniqKey="Combret S" first="S" last="Combret">S. Combret</name><affiliation wicri:level="3"><nlm:affiliation>Centre régional de pharmacovigilance, CHU Dijon bocage central, pôle des vigilances, 2, boulevard de Lattre-de-Tassigny, 21000 Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre régional de pharmacovigilance, CHU Dijon bocage central, pôle des vigilances, 2, boulevard de Lattre-de-Tassigny, 21000 Dijon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Manckoundia, P" sort="Manckoundia, P" uniqKey="Manckoundia P" first="P" last="Manckoundia">P. Manckoundia</name><affiliation wicri:level="3"><nlm:affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot CHU, BP 87909, 2, rue Jules-Violle, 21079 Dijon cedex, France; Inserm U1093 : cognition, action et plasticité sensorimotrice (CAPS), université de Bourgogne Franche-Comté, BP 27877, 21078 Dijon cedex, France. Electronic address: patrick.manckoundia@chu-dijon.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de médecine interne gériatrie, hôpital de Champmaillot CHU, BP 87909, 2, rue Jules-Violle, 21079 Dijon cedex, France; Inserm U1093 : cognition, action et plasticité sensorimotrice (CAPS), université de Bourgogne Franche-Comté, BP 27877, 21078 Dijon cedex</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal des maladies vasculaires</title><idno type="eISSN">2214-8116</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term><term>Atrial Fibrillation (drug therapy)</term><term>Biopsy</term><term>Digoxin (adverse effects)</term><term>Female</term><term>Humans</term><term>Vasculitis, Leukocytoclastic, Cutaneous (chemically induced)</term><term>Vasculitis, Leukocytoclastic, Cutaneous (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Biopsie</term><term>Digoxine (effets indésirables)</term><term>Femelle</term><term>Fibrillation auriculaire (traitement médicamenteux)</term><term>Humains</term><term>Sujet âgé de 80 ans ou plus</term><term>Vascularite leucocytoclasique cutanée ()</term><term>Vascularite leucocytoclasique cutanée (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Digoxin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Vascularite leucocytoclasique cutanée</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Vasculitis, Leukocytoclastic, Cutaneous</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Atrial Fibrillation</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Digoxine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Vasculitis, Leukocytoclastic, Cutaneous</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Fibrillation auriculaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Biopsy</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biopsie</term><term>Femelle</term><term>Humains</term><term>Sujet âgé de 80 ans ou plus</term><term>Vascularite leucocytoclasique cutanée</term></keywords><keywords scheme="mix" xml:lang="en"><term>Adverse side effects</term><term>Digoxin</term><term>Leukocytoclastic vasculitis</term></keywords><keywords scheme="mix" xml:lang="fr"><term>Digoxine</term><term>Effets indésirables</term><term>Vascularite leucocytoclasique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Even though digoxin causes many side effects, few cases of skin involvement are recorded in the French Pharmacovigilance Database. We report a case of leukocytoclastic vasculitis (LV) very probably due to digoxin. A 91-year-old woman, hospitalized following a fall, presented cardiac decompensation in a context of rapid atrial fibrillation requiring treatment with digoxin. Eight days later, a rash appeared on her back and trunk. It was neither itchy, nor painful and persisted despite local treatment. There were no other clinical anomalies. After a few days, the rash spread with appearance of bullous lesions, ulcerations and a necrosis on lymphedema of the two legs. Among the complementary examinations, skin biopsy revealed LV with necrosis and subepidermal detachment suggested toxic dermal necrolysis, while direct immunofluorescence was negative. The rash resolved progressively once the digoxin was stopped. The pharmacovigilance department recorded that digoxin was the probable cause. The evidence allowed us to conclude that digoxin was the cause.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li></region><settlement><li>Dijon</li><li>Fontaine-les-Dijon</li></settlement></list><tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Ludwig Beal, S" sort="Ludwig Beal, S" uniqKey="Ludwig Beal S" first="S" last="Ludwig-Béal">S. Ludwig-Béal</name></region><name sortKey="Combret, S" sort="Combret, S" uniqKey="Combret S" first="S" last="Combret">S. Combret</name><name sortKey="Leveque, L" sort="Leveque, L" uniqKey="Leveque L" first="L" last="Levêque">L. Levêque</name><name sortKey="Manckoundia, P" sort="Manckoundia, P" uniqKey="Manckoundia P" first="P" last="Manckoundia">P. Manckoundia</name><name sortKey="Popitean, L" sort="Popitean, L" uniqKey="Popitean L" first="L" last="Popitean">L. Popitean</name><name sortKey="Vernier, N" sort="Vernier, N" uniqKey="Vernier N" first="N" last="Vernier">N. Vernier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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